Preliminary clinical trial findings: Dexamethasone
In March 2020, the RECOVERY (Randomised Evaluation of COVid-19 thERapY) trial was established as a randomised clinical trial to test a range of potential treatments for COVID-19, including low-dose dexamethasone.
A total of 2104 patients were randomised to receive dexamethasone 6 mg once per day (either by mouth or by intravenous injection) for ten days and were compared with 4321 patients randomised to usual care alone. Dexamethasone reduced deaths by one-third in ventilated patients and by one fifth in other patients receiving oxygen only. There was no benefit among those patients who did not require respiratory support.
The peer reviewed and published article can be found below.
Preliminary clinical trial findings: Dexamethasone
In March 2020, the RECOVERY (Randomised Evaluation of COVid-19 thERapY) trial was established as a randomised clinical trial to test a range of potential treatments for COVID-19, including low-dose dexamethasone.
A total of 2104 patients were randomised to receive dexamethasone 6 mg once per day (either by mouth or by intravenous injection) for ten days and were compared with 4321 patients randomised to usual care alone. Dexamethasone reduced deaths by one-third in ventilated patients and by one fifth in other patients receiving oxygen only. There was no benefit among those patients who did not require respiratory support.
The peer reviewed and published article can be found below.
Resources
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Statement from the Chief Investigators of the RECOVERY Trial on dexamethasone
Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19.
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The RECOVERY Trial
The preliminary results of the controlled, open-label Randomized Evaluation of Covid-19 Therapy (RECOVERY) trial of dexamethasone in patients hospitalized with Covid-19.
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Effect of Dexamethasone in Hospitalized Patients with COVID-19 – Preliminary Report (pre print)
The results of a randomized controlled trial of dexamethasone in patients hospitalized with COVID-19.
